Radioprotective Capactivity of Emblica Officinalis against Radiation Induced Biochemical Alterations in Liver of Swiss Albino Mice

Radio protective effect of fruit extract of Emblica officinalis (EO) has been studied against lethal dose (7.5 Gy) of gamma radiation in the liver of Swiss albino mice at various post-irradiation intervals viz. 12 hrs, 24 hrs and 3rd, 5th, 10th,20th and 30th days. In control animals (without EO treated irradiated), an elevation in glycogen and protein content was found till day 3rd and 5th respectively. Thereafter, their levels decreased at consecutive intervals without reaching to normal. In this group of animals, cholesterol level is found to be significantly lower than normal at 12 hrs, but later increased at remaining intervals. Acid and alkaline phosphatases activities were significantly higher than the normal value at early intervals but later increased progressively. A similar pattern of biochemical alterations was exhibited by experimental group (EO pretreated irradiated) but to a lower extent. EO extract significantly delayed and inhibited the rise in biochemical parameters. The increased glycogen and protein activity was noted at day 3rd and 5th respectively, but it was found significantly lesser than the control. Normal values of these constituents were regained on day 20th; while in control animals, normal value was not ever attained. Cholesterol level declined significantly in comparison to control, but later elevated and reached to normal level. Variations in acid and alkaline phosphatases activities were found similar to that of control but their values were considerably lower and later attained the normal level before the end of study.